Poor Wound Healing Is Directly Related to These 6 Factors

Wounds are disruptions of the normal structure and function of the skin and underlying soft tissue . Normally, wounds heal through an orderly sequence of physiological events that involve hemostasis, inflammation, proliferation, and remodeling . However, some wounds fail to heal in a timely manner and become chronic, which can lead to complications such as infection, pain, and disability .

Chronic wounds are defined as wounds that have not healed significantly in four weeks or completely in eight weeks . They are often associated with underlying medical conditions that impair the healing process, such as diabetes, obesity, vascular disease, and malnutrition . In this article, we will discuss six factors that are directly related to poor wound healing and how they can be addressed.

1. Infection

Infection is one of the most common causes of delayed wound healing. When the skin is broken, bacteria can enter the wound and multiply, causing inflammation, tissue damage, and impaired healing . Signs of infection include redness, swelling, pain, pus, foul odor, and fever .

To prevent and treat infection, wounds should be cleaned and dressed regularly with sterile materials. Antibiotics may be prescribed by a doctor if the infection is severe or systemic. According to Healthline, some natural remedies that may help fight infection include honey, garlic, turmeric, and aloe vera .

2. Poor Circulation

Blood circulation is essential for wound healing, as it delivers oxygen, nutrients, and immune cells to the wound site and removes waste products and debris . Poor circulation can result from conditions such as diabetes, peripheral artery disease, and venous insufficiency, which reduce blood flow to the extremities .

Poor circulation can slow down or stop wound healing by depriving the wound of oxygen and creating a hypoxic environment that favors bacterial growth and tissue death . To improve circulation, patients should exercise regularly, elevate the affected limb, quit smoking, and wear compression garments if indicated .

3. Poor Nutrition

Nutrition plays a vital role in wound healing, as it provides the building blocks for new tissue formation and wound repair . Protein, in particular, is necessary for collagen synthesis, which is the main component of the extracellular matrix that supports wound healing . Other nutrients that are important for wound healing include vitamin C, zinc, iron, and antioxidants .

Poor nutrition can impair wound healing by compromising the immune system, increasing the risk of infection, and delaying the healing phases . To optimize nutrition, patients should eat a balanced diet that is rich in protein, fruits, vegetables, and whole grains, and drink plenty of water to stay hydrated .

4. Diabetes

Diabetes is a chronic condition that affects the body’s ability to regulate blood sugar levels. High blood sugar can damage the blood vessels and nerves, leading to poor circulation and neuropathy, which can impair wound healing . Diabetic patients are also more prone to infection, as high blood sugar can weaken the immune system and impair its response to bacteria .

Diabetes can also cause diabetic foot ulcers, which are open sores that develop on the feet due to pressure, friction, or trauma . These ulcers are difficult to heal and can lead to serious complications such as gangrene and amputation . To prevent and treat diabetic wounds, patients should control their blood sugar levels, inspect their feet daily, wear proper footwear, and seek medical attention if they notice any signs of infection or tissue damage .

5. Excessive Swelling

Swelling, or edema, is the accumulation of fluid in the tissues, which can occur due to injury, inflammation, infection, or venous insufficiency . Swelling can impair wound healing by compressing the blood vessels, reducing oxygen delivery, and interfering with cell migration and proliferation .

To reduce swelling, patients should elevate the affected area, apply cold or warm compresses, wear compression garments, and avoid salt and alcohol . If swelling persists or worsens, patients should consult a doctor to rule out any underlying conditions that may cause fluid retention, such as heart failure, kidney disease, or liver disease .

6. Medications

Some medications can affect wound healing by interfering with the inflammatory response, collagen synthesis, angiogenesis, or immune function . Examples of medications that can impair wound healing include steroids, nonsteroidal anti-inflammatory drugs (NSAIDs), anticoagulants, chemotherapy, and immunosuppressants .

Patients should inform their doctor about any medications they are taking, especially if they have a chronic wound or are undergoing surgery. The doctor may adjust the dose or switch to a different medication that has less impact on wound healing. Patients should never stop or change their medications without consulting their doctor, as this may cause adverse effects or complications .


Poor wound healing is directly related to several factors that can affect the wound environment, the healing process, and the patient’s overall health. By identifying and addressing these factors, patients can improve their chances of healing and prevent further complications. Patients should follow their doctor’s instructions on wound care, take their medications as prescribed, and seek medical attention if they notice any signs of infection, tissue damage, or delayed healing.